The Human Proteome Project: Current State and Future Direction

By P. Legrain, R. Aebersold, A. Archakov, Amos Bairoch, Kumar Bala, L. Beretta, J. Bergeron, C. Borchers, G. Corthals, C. Costello and 15 more. Molecular & Cellular Proteomics, 2011

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After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/ad2ab8bfe0d214a56c7de20d229081064c121f56

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Citations in the corpus

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations (2014, background): “These include: the Human Protein Atlas (http://www.proteinatlas.org/) for protein expression levels and subcellular localization based on immunohistochemistry, and transcript expression levels for a large number of human tissues, cancers and cell lines (16); BioGPS (http://biogps.org/) for tissue-sp”
Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins (2012, background): “overlap of expressed genes in different cell types (2, 35, 36).”