Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3

By R. May, E. Caron, A. Hall, L. Machesky. Nature Cell Biology, 2000

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Phagocytosis and the actin cytoskeleton. (2001, background): “Previously shown to localise to lamellipodia of crawling cells (Machesky et al., 1997; Welch et al., 1997), the Arp2/3 complex also localises to both FcγR- and CR3mediated phagosomes, and is required for particle uptake through both receptors (May et al., 2000).”
Rho GTPases and cell migration. (2001, result): “In the latter case, Rho might link to the Arp2/3 complex, which is consistent with the observation that Rho and the Arp2/3 complex but not Rac/Cdc42 are required for integrin-mediated phagocytosis (May et al., 2000).”
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. (2003, background): “Importantly, properly localized Ena/VASP proteins and Arp2/3 are each required for effective Jurkat T cell polarization and for phagocytosis (Coppolino et al. 2001, Krause et al. 2000, May et al. 2000), suggesting that Ena/VASP-WASP-Arp2/3 networks may function together to promote these processes.”