Poly(ADP-ribose) (PAR) polymer is a death signal
By Shaida A. Andrabi, N. Kim, Seong-Woon Yu, Hongmin Wang, D. Koh, M. Sasaki, Judith A. Klaus, Takashi Otsuka, Zhizheng Zhang, R. Koehler and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2006
640 citations recorded by the source corpus.
Subfields: Electrical and Electronic Engineering, Oncology
View Paper: https://www.semanticscholar.org/paper/acb41cd1652155e21a8ea5bfe0d918c38c78d607
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- M. Fricker
- A. Tolkovsky
- V. Borutaite
- Michael Coleman
- A. Nunes‐Nesi
- Alisdair R. Fernie
- Guy C. Brown
- Linda de Bont
Citations in the corpus
- NAD+ Biosynthesis and Signaling in Plants (2018, background): “ADP-ribose units to proteins, releasing nicotinamide and forming long toxic and cell-induced ADP-ribose chains (Andrabi et al., 2006) with simultaneous depletion of ATP (Amor et al.”
- Neuronal Cell Death. (2018, positive): “The product of PARP activity, PAR, induces AIF nuclear translocation and also causes bioenergetic collapse through inhibition of the glycolytic enzyme hexokinase, resulting in necrosis (8, 14).”