Antibacterial natural products in medicinal chemistry--exodus or revival?

By F. von Nussbaum, M. Brands, B. Hinzen, S. Weigand, D. Häbich. Angewandte Chemie, 2006

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A Historical Overview of Natural Products in Drug Discovery (2012, background): “As a result, many of the pharmaceutical companies disbanded or sold their collections of screening extracts [121,122] as it was believed that traditional extract-based screening resulted in the continuous re-discovery of previously isolated compounds and that the structural complexity of natural pro”
New antibiotics from bacterial natural products (2006, background): “,” new antibiotics from the subsequent decades have come from iterative, semisynthetic tailoring of the natural scaffolds to create successive generations of antibiotics (for example, erythromycin → clarithromycin → telithromycin”