Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

By V. Lallemand-Breitenbach, M. Jeanne, S. Benhenda, R. Nasr, M. Lei, L. Pérès, Jun Zhou, Jun Zhu, B. Raught, H. Thé. Nature Cell Biology, 2008

702 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac7a5fb2bc4b8e7b72d4383fe353c501ea3fb257

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Daniela Hoeller
2. Ivan Dikic
3. C. Lima
4. Jaclyn R. Gareau

Citations in the corpus

• Targeting the ubiquitin system in cancer therapy (2009, background): “RNF4 has an important role in APL, as it recognizes SUMOylated PML as well as the APL-associated oncogenic fusion protein PML–RAR-α, and triggers their polyubiquitin-dependent proteasomal degradatio”
• The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (2010, background): “The presence of multiple SIMs in these ubiquitin ligases is noteworthy because tandem SIMs could recognize two or more SUMO molecules in a SUMO chai”