Role of LAG-3 in regulatory T cells.

By Ching-Tai Huang, C. Workman, D. Flies, Xiaoyu Pan, A. L. Marson, Gang Zhou, Edward L. Hipkiss, S. Ravi, J. Kowalski, H. Levitsky and 4 more. Immunity, 2004

1,284 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ac134d6ec5c127f377cce40cfa270bdbc9769279

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Citations in the corpus

Regulatory T cells: how do they suppress immune responses? (2009, background): “Lymphocyte activation gene 3 (LAG- 3; CD223), a CD4-related, activation-induced cell surface molecule highly expressed on Foxp3+ Tregs, also plays a role in Treg‐APC interaction ( 25 ).”
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 (2019, background): “Their results showed that dual blockade of LAG-3 and PD-1 synergistically enhanced anti-tumor immunity and suppressed tumor growth by enhancing CD8+ tumor infiltrating T cells (TILs) and decreasing regulatory T cells (Tregs) in the tumor microenvironment (TME) [37].”
How regulatory T cells work (2008, background): “LAG3 is a CD4 homologue that binds MHC class II molecules with very high affinity, has a negative regulatory T-cell intrinsic function and is required for maximal T Reg -cell suppressio”
Mechanisms of immune evasion by tumors. (2006, background): “Other potential Treg markers include the glucocorticoid‐induced TNF receptor (GITR) (McHugh et al., 2002), neuropilin (Bruder et al., 2004), and lymphocyte activation gene‐3 (Lag‐3) (Huang et al., 2004).”
Mucosal immunity and vaccines (2005, background): “Notably, these cells may also confer suppressor activity on other CD4 + T cells by inducing the expression of the transcription factor Foxp3 and/or the major histocompatibility complex (MHC) class II–binding molecule LAG-3 in such cells ('infectious tolerance'”
Coregulation of CD8+ T cell exhaustion during chronic viral infection by multiple inhibitory receptors (2008, background): “Although a function for LAG-3 has been reported on regulatory T cell”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “for maximal suppressive activity of both natural and induced Treg cells (210).”
Cancer immunotherapy comes of age (2011, neutral): “Not as well studied as CTLA4, LAG-3 appears similar in that it acts to limit the activity of CD4 + and CD8 + T cells, and augment the activity of T reg cell”
The blockade of immune checkpoints in cancer immunotherapy (2012, background): “In addition to providing inhibitory signals to activated effector T cells, some of these receptors, such as LAG3, are highly expressed on T Reg cells, where they are important for amplifying the immunosuppressive activity of T Reg cell”
Immune checkpoint blockade: a common denominator approach to cancer therapy (2015, background): “Early studies showed that LAG-3 was selectively upregulated on CD4+ Tregs (Huang et al., 2004).”