Cytokine Production and Treatment Response in Major Depressive Disorder

By S. Lanquillon, J. Krieg, U. Bening-Abu-Shach, H. Vedder. Neuropsychopharmacology, 2000

759 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/ac11a4e2bf4b6858c7996f684b1514a96885eeaf

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Citations in the corpus

Curcumin and cancer: an "old-age" disease with an "age-old" solution. (2008, background): “[249] S.”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “Altogether, these findings suggest that the effects of antidepressants on cytokines remain unclear, though it is generally thought that antidepressants shift the balance toward an anti-inflammatory response (Kubera et al., 2001b; Lanquillon et al., 2000; Maes et al., 1999; Sluzewska et al., 1997).”
Inflammation and clinical response to treatment in depression: A meta-analysis. (2015, neutral): “…Mikova et al., 2001; Piletz et al., 2009; Song et al., 2009; Tuglu et al., 2003; Yoshimura et al., 2009) and CRP in 8 studies (Chang et al., 2012; Harley et al., 2010; Lanquillon et al., 2000; O'Brien et al., 2006; Piletz et al., 2009; Tsai et al., 2014; Tuglu et al., 2003; Uher et al., 2014).”
Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels (2019, background): “Poor response to antidepressants is associated with the activation of inflammatory immune responses (Lanquillon et al., 2000; Benedetti et al., 2002; Carvalho et al., 2013; Chamberlain et al., 2018).”
Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…have been reported (Molendijk et al., 2011, Rojas et al., 2011), as have decreased circulating cytokines, such as IL-6 (Frommberger et al., 1997, Lanquillon et al., 2000), Therefore, prospective studies examining transcriptomic changes over time, such as this one, may be useful in identifying…”
Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. (2011, background): “For example, maltreated individuals tend to have elevated inflammation levels (7, 9), which have been associated with recurrent depressive episodes (10) and poor treatment response (11).”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…with non-response to treatment with conventional antidepressant medications as well as early life stress, which is likewise associated with an antidepressant treatment non response (Sluzewska et al., 1997; Lanquillon et al., 2000; Nemeroff et al., 2003; Danese et al., 2007; Danese et al., 2008).”
Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls (2020, methodology): “The final data set included 107 studies (Lanquillon et al., 2000; Maes et al., 1997; O’Brien et al., 2007; Alcocer-Gómez et al., 2014; Alesci et al., 2005; Ali et al., 2018; Bai et al., 2014; Basterzi et al., 2005; Berk et al., 1997; Boettger et al., 2010; Brambilla and Maggioni, 1998; Camardese et…”
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “A study of 24 MDD inpatients showed that higher IL-6 levels predict non-response to a six-week treatment with amitriptyline, while TNF-α levels were high in both responders and non-responders, but only decreased during treatment in responders [148].”
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014, positive): “Although previous studies have identified elevated serum IL-6 and circulating leukocytes in stress disorders, this generally followed either depression diagnosis in humans (4, 25) or controlled stress exposure in rodents (26, 27).”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “For example, patients with evidence of increased inflammatory activity prior to treatment have been reported to be less responsive to antidepressants, lithium, or sleep deprivation (a potent short-term mood elevator) (106-108).”
Cytokines sing the blues: inflammation and the pathogenesis of depression. (2006, background): “In humans, a variety of antidepressant strategies (including medication, electro-convulsive shock therapy and psychotherapy) appear to attenuate inflammatory activity in concert with improvements in depressive symptoms, suggesting that reductions in inflammation might contribute to treatment respons”