The P53 pathway: what questions remain to be explored?

By Arnold J. Levine, Wenwei Hu, Zhaohui Feng. Cell Death and Differentiation, 2006

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Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…through its function as a transcription factor: Upon being post-translationally modified by various genotoxic and cytotoxic stress-sensing agents, p53 is stabilized, then binds and transcriptionally regulates the promoters of >2500 potential effector genes (Hoh et al. 2002; Levine et al. 2006).”
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. (2007, background): “The p53 protein plays a central role in integrating various stress signals and can be activated by various stresses (21, 38).”
A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 response (2010, background): “Collectively, these results indicate that lincRNA-p21 acts to repress many genes in p53-dependent transcriptional response. lincRNA-p21 Regulates Apoptosis The activation of the p53 pathway has two major phenotypic outcomes: growth arrest and apoptosis (Levine et al., 2006).”