Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection.

By I. Youngster, G. Russell, Christina Pindar, T. Ziv-Baran, J. Sauk, E. Hohmann. Journal of the American Medical Association (JAMA), 2014

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Current understanding of dysbiosis in disease in human and animal models (2016, background): “Recent reports have demonstrated the development of capsulated frozen inoculum that can be administered orally with no apparent side effects and thus avoids unnecessary invasive gastrointestinal procedures (2012).(94) Notably, the best example of how FMT can ameliorate disease is in the case of C.”
Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. (2016, background): “Antibiotic use prior to first FMT 58 (13-645) 43.”
Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “The efficacy of the first dose was about 52–70%, which is lower than that of other methods of administration, such as colonoscopy; but after examination of several rounds of treatment are administered to the patient, the result were similar to those of colonoscopy (Youngster et al., 2014a; Hirsch et”