Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.

By David Reffitt, N. Ogston, R. Jugdaohsingh, H. Cheung, B. A. J. Evans, R. Thompson, Jonathan J. Powell, Geeta Hampson. Bone, 2003

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Bone grafts and biomaterials substitutes for bone defect repair: A review (2017, background): “dose-dependent enhancement of osteoblast proliferation, differentiation and collagen production were observed in vitro [281,343].”
Chitin and collagen as universal and alternative templates in biomineralization (2010, background): “- Orthosilicic acid stimulated collagen I synthesis by human osteoblast-like cells in vitro and enhances osteoblastic differentiation (Reffitt et al. 2003).”
Review of bioactive glass: from Hench to hybrids. (2013, background): “thought to be released from the glass in the form of silicic acid (Si(OH)4), which has been shown to stimulate collagen I production by human osteoblast cells at a concentration of 10 mmol [125].”
Sol-gel based materials for biomedical applications (2016, background): “In addition, single inorganic ions such as calcium [341,342], phosphorous [343], and silicon [344,345] are known to be involved in bone metabolism and to play a physiological role in angiogenesis, growth and mineralization of bone tissue.”
Silicon substitution in the calcium phosphate bioceramics. (2007, positive): “2 times increases in alkaline phosphatase and osteocalcin activities, implying an associated increase in osteogenesis [21].”