A bioorthogonal system reveals antitumour immune function of pyroptosis

By Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, F. Shao, Zhibo Liu. Nature, 2020

875 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ab5b4aa06256ce780c633664df39f0b54f270033

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Yan Yu
2. Weitong Gao
3. Yang Zhou
4. Xuepeng Wang

In Molecular Biology

1. Yan Yu
2. Weitong Gao
3. Yang Zhou
4. Xuepeng Wang

Citations in the corpus

• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, methodology): “PYROPTOSIS SYNERGIZES ANTITUMOR IMMUNE RESPONSE Two concurrently published studies have found that tumor cells released danger signals that recruited antitumor immune cells through pyroptosis while immune cells induced pyroptosis in tumor cells, thereby establishing a positive feedback loop.(29,31) ”
• Pyroptosis in inflammatory diseases and cancer (2022, background): “constructed a nano-bioorthogonal chemical system, in which gasdermin A3 (GA3) was linked to nanoparticles via the trimethylsilyl ether linker (NP-GA3), and this linker could be cleaved by a cancer-imaging probe phenylalanine trifluoroborate (Phe-BF3) [124].”
• Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “found that in the presence of pyroptosis, ICI-based therapies were effective in killing cold tumor cells, which is attributed to the fired up TME caused by pyroptosis-induced inflammation [341].”
• Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “At present, immune checkpoint inhibitors (ICI) have broad application prospects in clinical tumor treatment, but relevant data show that only 1/3 of patients respond to ICI.356 There is a synergistic effect between cell focal death and ICI.”
• Role of pyroptosis in inflammation and cancer (2022, background): “Researchers have established a bioorthogonal chemical system consisting of a cancer imaging probe, phenylalanine trifluoroborate (PH-BF3), and nanoparticles (NPs) that can enter tumor cells as a delivery system [246].”