The enzymes, regulation, and genetics of bile acid synthesis.

By David W. Russell. Annual Review of Biochemistry, 2003

1,985 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/ab58b1af38f93602dbfdcf7ba9125b9cbfb5b8c3

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In Molecular Biology

1. J. Y. Chiang
2. Tiangang Li
3. Stanley L Hazen
4. H. Ji
5. Hanns-Ulrich Marschall
6. W. Tang
7. A. Moser
8. Bart Staels

In Oncology

1. J. Y. Chiang
2. Tiangang Li
3. F. Bäckhed
4. Hanns-Ulrich Marschall
5. A. Moser
6. P. Edwards
7. Min-Sun Kim
8. C. Grunfeld

In Surgery

1. J. Y. Chiang
2. Hanns-Ulrich Marschall
3. A. Moser
4. Tiangang Li
5. P. Edwards
6. Bart Staels
7. Min-Sun Kim
8. C. Grunfeld

Citations in the corpus

• Targeting bile-acid signalling for metabolic diseases (2008, background): “Bile-acid biosynthesis involves modification of the ring structure of cholesterol, oxidation and shortening of the side chain, and finally conjugation of the bile acid with an amino aci”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Intestinal microbiota are capable of producing secondary bile acids from ∼5 to 10% of hepatic-derived bile acids that affect host physiology by serving as FXR agonists, thus resulting in a smaller bile acid pool due to the inhibition of primary bile acid synthesis (692, 693).”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Bile acid synthesis is a multistep reaction that involves enzymes localized in the endoplasmic reticulum (ER), mitochondria, cytosol, and peroxisomes (Russell, 2003).”
• Effect of dietary bile acids on growth, body composition, lipid metabolism and microbiota in grass carp (Ctenopharyngodon idella) (2018, background): “In fact, several studies have reported that other FXR- independent mechanisms (i.e., accumulation of bile acids, circadian rhythm, and/or other nuclear receptors) are involved in the regulation of CYP7A1 expression by bile acids (Russell, 2003).”
• Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. (2016, positive): “The alternative (or acidic) pathway is initiated by sterol-27-hydroxylase (CYP27A1) (Russell, 2003).”
• Bile acids: regulation of synthesis (2009, neutral): “acid) and chenodeoxycholic acid (CDCA, 3α, 7α-dihydroxy-cholanoic acid) (Fig 1) (40).”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “the microbiota in the lower part of the small intestine and the colon.(107,108) BAs facilitate the absorption of dietary fat and fat-”