Effects of MicroRNA‐29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma

By Yujuan Xiong, Jian‐Hong Fang, J. Yun, Jine Yang, Ying Zhang, W. Jia, Shi-Mei Zhuang. Hepatology, 2009

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microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer (2011, background): “miRNA-dependent regulation of MEG3 expression Reduced expression of miR-29 is a frequent event in HCC and is correlated with a poor prognosis (Xiong et al., 2010).”
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ (2011, background): “Members of the miR-29 family are important regulators of human disease”
Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis (2011, background): “Furthermore, down-regulation of miR29 is found in various types of cancers, such as hepatocellular carcinoma.(21,22) Therefore, miR-29 also might play a crucial role in the transition from liver cirrhosis to the development of hepatocellular carcinoma.”