Clinical characteristics of 2019 novel coronavirus infection in China

By W. Guan, Zheng-yi Ni, Yu Hu, W. Liang, C. Ou, Jianxing He, Lei Liu, H. Shan, C. Lei, D. Hui and 27 more. medRxiv, 2020

1,814 citations recorded by the source corpus.

Background: Since December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases. Methods: We extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals in 31 provinces/provincial municipalities through January 29th, 2020. Results: The median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P<0.001). Lymphopenia was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia was independently associated with either the admission to intensive care unit, mechanical ventilation, or death in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67). Conclusions: The 2019-nCoV epidemic spreads rapidly by human-to-human transmission. Normal radiologic findings are present among some patients with 2019-nCoV infection. The disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count and chest X-ray/CT manifestations) predict poor clinical outcomes.

Subfields: Infectious Diseases, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/aaf1c698f1df87f35f9110f57d3064f7ed157e53

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In Infectious Diseases

R. Aftab

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Coronavirus Disease 19 (COVID-19): Implications for Clinical Dental Care (2020, background): “It is worth noting that case presentations can be dynamic, and there is a good chance that dental practices might treat some of the patients with asymptomatic COVID-19 infections since the incubation period can range from 0 to 24 days and most patients only develop mild symptoms 14, 16 .”
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Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis (2020, neutral): “Wu et al. 2020 [26] NR 2.5 (CLD) 84/201 (41%), ARDS 1080 (720–1450) 670 (490–990) NR NR NR Liu et al. 2020 [27] NR 3.7 53/109 (48%), ARDS 1000 (800–1400) 700 (400–1100) NR NR NR Guan et al. 2020 [28] 14.4 1.1 173/1099 (15%), severe 1000 (800–1400) 800 (600–1000) ≤ 1500 584/726 (83.2”
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