Cognitive impairment in schizophrenia is the core of the disorder.

By Brita Elvevåg, Terry E. Goldberg. Critical Reviews in Neurobiology, 2000

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Interneuron dysfunction in psychiatric disorders (2012, background): “Although positive symptoms are the most noticeable manifestations of this disease, cognitive deficits are perhaps the most distinctiv”
Cortical inhibitory neurons and schizophrenia (2005, background): “Of the many clinical features of schizophrenia, disturbances in certain cognitive processes, such as impairments in attention, memory and executive functions (that is, the ability to plan, initiate and regulate goal-directed behaviour), might represent the core features of the illnes”
Openness and extraversion are associated with reduced latent inhibition: replication and commentary (2002, background): “Second, there is evidence for relatively specific working memory and attention deficits among schizophrenics and schizotypes (Elvevag & Goldberg, 2000; Kenny et al., 1999; Kirrane & Siever, 2000).”
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “The intermediate (schizophrenia) phenotypes, of moderately diminished premorbid IQ and related cognitive measures (Elvevag and Goldberg 2000; Weickert et al. 2000), may be an interesting connection between the function of the DPC in synaptic transmission and the observed association between…”