Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.

By Brian J Cummings, N. Uchida, S. Tamaki, Desiree Salazar, Mitra J. Hooshmand, R. Summers, Fred H. Gage, A. Anderson. 2005

747 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Z. Kokaia
2. O. Lindvall
3. Arne May
4. M. Elnaggar
5. G. Martino
6. Giorgia Quadrato
7. S. Pluchino
8. S. Di Giovanni

In Developmental Neuroscience

1. S. Pluchino
2. G. Martino
3. Z. Kokaia
4. O. Lindvall
5. Arne May
6. M. Elnaggar
7. Giorgia Quadrato
8. S. Di Giovanni

Citations in the corpus

• Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “The therapeutic potential of the transplanted stem cells have been validated in various models of diseases and injuries (Shihabuddin et al., 2000; Pluchino et al., 2003; Cummings et al., 2005; Jin et al., 2005).”
• Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury (2012, neutral): “Previous studies of embryonic stem cell implants to sites of spinal cord injury used moderate and incomplete lesions and reported only modest functional improvements (Cummings et al., 2005) (1–2 points on the BBB scale), with relatively modest graft survival in the lesion site.”
• The therapeutic potential of neural stem cells (2006, background): “Embryonic, foetal and neonatal cerebellar NPCs injected into models of SCI do not differentiate into terminally differentiated neuronal cell”
• Stem cells for the treatment of neurological disorders (2006, background): “A recent study showed that human NS cells implanted into damaged mouse spinal cord generated new neurons and oligodendrocytes, leading to locomotor recover”
• Training-induced structural changes in the adult human brain. (2008, background): “Based on evidence from stem cells studies reporting three months needed by newly generated stem cells to differentiate into neurons [25] we decided for the same temporal extend between MRI scans studying longitudinally morphometric changes related to memory and learning [31].”