Molecular pathophysiology of cerebral hemorrhage: Secondary brain injury

By J. Aronowski, Xiurong Zhao. Stroke, 2011

779 citations recorded by the source corpus.

Intracerebral hemorrhage (ICH) is an often fatal type of stroke which kills about 30,000 people annually in the USA. If the patient survives the ictus, the resulting hematoma within brain parenchyma triggers a series of adverse events causing secondary insults and severe neurological deficits. This article discusses selected aspects of secondary brain injury after ICH and outlines key mechanisms associated with hematoma toxicity, oxidative stress, and inflammation. Finally, this review discusses the relevance of hematoma resolution processes as a target for ICH therapy, and presents potential clinically relevant molecular targets that could be harnessed to treat secondary injury associated with ICH injury.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/aa71f35dec125cff366e470da35152022ca41191

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Guy C. Brown
2. Michael Coleman
3. V. Borutaite
4. M. Fricker
5. A. Tolkovsky

In Neurology

1. Michael Coleman
2. V. Borutaite
3. M. Fricker
4. A. Tolkovsky
5. Guy C. Brown

Citations in the corpus

• Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives (2020, background): “In subarachnoid hemorrhage, blood accumulates in the subarachnoid space of the brain due to a head injury or cerebral aneurysm (Figure 1) [27,28].”
• Neuronal Cell Death. (2018, positive): “In general, it is thought that the main mechanisms of neuronal death in hemorrhagic stroke are excitotoxicity, toxicity of blood, oxidative stress, and inflammation (19, 705).”