LXRS and FXR: the yin and yang of cholesterol and fat metabolism.

By Nada Y. Kalaany, D. Mangelsdorf. Annual Review of Physiology, 2006

598 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/aa59015d8280968364ed29c1acf63be81c84d318

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In Molecular Biology

1. D. Nebert
2. M. Schoeler
3. Robert Caesar
4. T. Dalton
5. A. Jetten

In Oncology

1. P. Edwards
2. D. Nebert
3. T. Dalton
4. A. Jetten

In Surgery

1. P. Edwards
2. D. Nebert
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Citations in the corpus

• The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis (2006, background): “Is it possible that there is a 'regulatory-loop' paradigm with the farnesoid X receptor ( FXR ), bile acids, CYP7A1 and CYP8A1, and immune cell”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, unknown): “In hepatocytes, FXR is an important regulator of bile acid synthesis, detoxification and transport (for recent reviews including overviews of FXR target genes see (Calkin and Tontonoz 2012; Modica et al. 2010; Lefebvre et al. 2009; Keitel et al. 2008a; Thomas et al. 2008; Kalaany and Mangelsdorf 200”
• Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “Instead, Cyp7A1, the rate-limiting enzyme involved in the conversion of cholesterol to bile acids (Kalaany and Mangelsdorf, 2006), as well as other enzymes in the bile acid synthesis pathway, were decreased in SIRT1 LKO mice (Figure 6J), suggesting that the accumulation of hepatic cholesterol may be”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Several metabolic genes regulated by RORs have been reported to be target genes of other nuclear receptors [Akiyama and Gonzalez, 2003; Kalaany and Mangelsdorf, 2006; Kliewer, 2003; Qatanani and Moore, 2005; Runge-Morris and Kocarek, 2005].”
• Pleiotropic Roles of Bile Acids in Metabolism (2013, background): “The functional PXR/RXR heterodimer is promiscuous, as it is activated by numerous xenobiotics, pharmaceutical drugs, and specific bile acids.”
• Dietary lipids, gut microbiota and lipid metabolism (2019, background): “FXR is involved in the regulation of lipid metabolism, especially triglyceride trafficking, synthesis and utilization [71].”