Converging roles of caspases in inflammasome activation, cell death and innate immunity

By S. Man, T. Kanneganti. Nature reviews. Immunology, 2015

628 citations recorded by the source corpus.

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis, respectively. However, recent studies have revealed that these caspases have functions beyond their established roles. In addition to mediating cleavage of the inflammasome-associated cytokines interleukin-1β (IL-1β) and IL-18, inflammatory caspases modulate distinct forms of programmed cell death and coordinate cell-autonomous immunity and other fundamental cellular processes. Certain apoptotic caspases assemble structurally diverse and dynamic complexes that direct inflammasome and interferon responses to fine-tune inflammation. In this Review, we discuss the expanding and interconnected roles of caspases that highlight new aspects of this family of cysteine proteases in innate immunity.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/aa31fced4cefd35a46b04a9d7d2493da23afda26

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Kanneganti
2. R. Malireddi
3. S. Kesavardhana

In Molecular Biology

1. T. Kanneganti
2. R. Malireddi
3. S. Kesavardhana
4. D. Sharma
5. Yaqiu Wang

In Surgery

1. R. Malireddi
2. S. Kesavardhana
3. T. Kanneganti

Citations in the corpus

• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “The caspases are produced as enzymatically inactive zymogens called procaspases (4, 5) that undergo dimerization or oligomerization for activation.”
• The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, background): “For this reason, it is not widely accepted as an inflammasome platform (Man and Kanneganti, 2016).”
• ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “It is now established that pyroptosis is executed by gasdermin D (GSDMD)-mediated membrane lysis as a result of cleavage by inflammatory caspases to release the functionally active N-terminal fragment (Kayagaki et al., 2015; Shi et al., 2015; Man and Kanneganti, 2016; Van Opdenbosch and Lamkanfi, 20”
• ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways (2016, neutral): “Distinct forms of programmed cell death, including pyroptosis, necroptosis and apoptosis, are initiated by context-specific stimuli encountered by the cell (15).”
• Role of pyroptosis in inflammation and cancer (2022, background): “The definition of pyroptosis has expanded to include cell death triggered by many other caspases, including caspase-4/5/11 [15].”