Kinetic analysis of translocation through nuclear pore complexes

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Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. (2002, background): “…by the binding of intracellular import receptors to the NLSs. Consistent with this, the interaction between the two receptors, termed importin (karyopherin) ␣ and ␤, for classical NLSs, was speculated to increase the diameter of the transported complex by ϳ8 nm (Ribbeck and Gö rlich, 2001).”
Molecular mechanism of the nuclear protein import cycle (2007, background): “1 ) generates transport rates of ∼100–1,000 cargoes per minute per NP”
Proteomic analysis of the mammalian nuclear pore complex (2002, background): “Although several models have been proposed (Rout et al., 2000; Macara, 2001; Ribbeck and Görlich, 2001), the mechanism by which these FG repeat domains mediate active transport is poorly understood.”
Imaging Native β-Actin mRNA in Motile Fibroblasts (2004, background): “It has been shown that although the speed of nucleocytoplasmic transport drops by decreasing the temperature, its fundamental characteristics remain unchanged (Ribbeck and Gorlich, 2001).”
Transport into and out of the Nucleus (2001, background): “and 2,500 dimers/pore/s at 100 M NTF2 dimer) (204).”
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion (2002, methodology): “non-®xed samples using time-lapse confocal laser scanning microscopy as described previously (Ribbeck and GoÈrlich, 2001).”