The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

By Katharina Ribbeck, D. Görlich. EMBO Journal, 2002

617 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2e4d495b76659537a09bea7de9c1c20f64469319

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Citations in the corpus

The nuclear pore complex and nuclear transport. (2010, background): “2006; Frey and Gorlich 2007), originally the “hydrophobic gel” model (Ribbeck and Gorlich 2002).”
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Second, we perturbed nuclear pore permeability by disrupting FG interactions with trans1-2 cyclohexanediol (CHD) (Ribbeck and Görlich, 2002) and Pitstop2 (Liashkovich et al.”
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015, positive): “Interestingly, LLPS by A1-FL was disrupted by hexanediol, a compound that disables the selectivity filter of the nuclear pore complex by disrupting the interactions of phenylalanines in the FG repeats (Patel et al., 2007; Ribbeck and Görlich, 2002), suggesting that aromatic residues in the LCD contr”
Stochastic models of intracellular transport (2013, methodology): “…models include the Entropic Gate model (Rout et al., 2003; Zilman et al., 2007), Selective Phase models (Bickel and Bruinsma, 2002; Kustanovich and Rabin, 2004; Ribbeck and Gorlich, 2001, 2002), Dimensionality Reduction model (Peters, 2005), and the Polymeric Brush model (Lim et al., 2007, 2006).”
Controlled microfluidic interfaces (2005, background): “Basic cellular transport mechanisms might be studied using engineered controlled interfaces to validate proposed models, such as the selective phase model for transport through nuclear pore complexes by hydrophobic exclusio”
Distinct stages in stress granule assembly and disassembly (2016, methodology): “In contrast, small aliphatic molecules, such as 1,6-Hexanediol, are hypothesized to perturb weak hydrophobic interactions, and thus disassemble assemblies that exhibit liquid-like properties in vitro (Patel et al., 2007; Ribbeck and Görlich, 2002).”
Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments (2017, background): “Hexanediol was shown to perturb FG repeat interactions between nucleoporins in nuclear pores [6] [7] and interactions between RNAbinding proteins in RNA-protein granules (RNP) [2] [8].”