Revisiting STAT3 signalling in cancer: new and unexpected biological functions

By Hua Yu, Heehyoung Lee, A. Herrmann, R. Buettner, R. Jove. Nature Reviews. Cancer, 2014

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Oral squamous cell carcinomas: state of the field and emerging directions (2023, background): “…in response to upstream signals from the IL-6 receptor family and RTKs including EGFR, VEGFRs, Jenus-activated kinases (JAKs), and Src family kinases (SFKs), STAT3 is activated and translocated to the nucleus, 119 thereby inducing the expression of cyclin D1, Bcl-xL, and other pro-survival factors.”
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer (2023, background): “Several studies have shown that STAT3 plays a central role in the proliferation, invasion, metastasis, and immune escape of breast cancer cells.(321,322) Moreover, STAT3 helps maintain the phenotype and function of breast cancer stem cells (BCSCs), which display pluripotent properties, resistance to”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “In addition to NF-κ B activation, TLRs such as TLR2, TLR4, TLR7 and TLR9 activate STAT3 (206, 325).”
Macrophages and therapeutic resistance in cancer (2015, positive): “STAT3 activation promotes neoplastic cell proliferation and survival, and multiple tumor cell lines exhibit IL-6- or STAT3-dependent chemoresistance in vitro (Taniguchi and Karin, 2014; Yu et al., 2014).”