Obstructive sleep apnea is independently associated with insulin resistance.

By M. Ip, B. Lam, M. Ng, W. Lam, K. Tsang, K. Lam. American Journal of Respiratory and Critical Care Medicine, 2002

1,281 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/a9ae2684d1d5f8780012c00838f2eb65508302a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. B. J. Gersh
2. Virend K. Somers
3. P. Trayhurn

In Endocrine and Autonomic Systems

1. T. Young
2. Naresh M. Punjabi
3. Paul E. Peppard
4. D. Gottlieb
5. E. Lindberg
6. K. Franklin
7. J. Skatrud
8. Virend K. Somers

In Physiology

1. Naresh M. Punjabi
2. T. Young
3. Paul E. Peppard
4. D. Gottlieb
5. E. Lindberg
6. K. Franklin
7. Jianping Ye
8. Virend K. Somers

Citations in the corpus

• Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. (2007, background): “hypoxia, such as obstructive sleep apnea (20, 40, 50, 56).”
• Mechanisms of insulin resistance in obesity (2013, background): “In clinic, obstructive sleep apnoea (OSA, sleep apnea) is associated with insulin resistance in obese subjects [104].”
• Population-Level Prediction of Type 2 Diabetes From Claims Data and Analysis of Risk Factors (2015, positive): “60 We also found other makers of cardiovascular disease, such as coronary atherosclerosis (Supplementary Table S2), hypertension (Tables 3 and 4), and kidney disease (Table 4 and Supplementary Tables S1–S3), to be predictive of diabetes onset.”
• Obesity: Risk factors, complications, and strategies for sustainable long‐term weight management (2017, background): “To start, a number of the conditions associated with obesity such as insulin resistance (Ip et al., 2002), systemic inflammation, and dyslipidemia are themselves closely associated with S5 OSA, and concurrently, the obesity-associated deposition of fat around the upper airway and thorax may affect…”
• Association of sleep apnea and type II diabetes: a population-based study. (2005, background): “Several cross-sectional studies have indicated that increasing levels of AHI are independently associated with worsened insulin resistance and glucose intolerance (6–9).”
• Pathophysiology of sleep apnea. (2010, background): “Independent associations exist between OSA and major risk factors for atherosclerosis, including hypertension (502) as well as insulin resistance (268) and hypercholesterolemia (104) (see sect.”