Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

By Yan Li, Qiupeng Zheng, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang-xia Zhao, Di Chen, J. Gu, Xianghuo He, Shenglin Huang. Cell Research, 2015

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Circular RNA Expression: Its Potential Regulation and Function (2016, background): “Additionally, circRNA may be abundant and stable in extracellular space or even secreted by exosomes [60].”
The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “In 2015, circRNAs were proposed as cancer biomarkers, and could be detected in the exosome [174].”
CircRNA: a novel type of biomarker for cancer (2017, background): “With the exception of the peculiar expression in tissues, circRNAs are also found in saliva [25] and exosomes [28], and it is believed that circRNAs are also regarded as a biological governor.”
Circular RNA: metabolism, functions and interactions with proteins (2020, background): “be regulated by associated miR levels in producer cells, while the specific biological activities transferred to recipient cells are largely unknown in diverse settings [48, 49].”
CircNet: a database of circular RNAs derived from transcriptome sequencing data (2015, background): “The fact that cell free circRNAs were found stable in saliva (29) as well as exosomes (30) makes circRNA a promising diagnosis biomarker.”
Exosomes: key players in cancer and potential therapeutic strategy (2020, result): “For the detection of circ-KLDHC10 in the exosomes of CRC patients, the expression level of circKLDHC10 in serum exosomes was compared to distinguish colon cancer patients from healthy controls.(67)”