Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial
By B. Auvert, D. Taljaard, E. Lagarde, J. Sobngwi-Tambekou, R. Sitta, A. Puren. PLoS Medicine, 2005
2,689 citations recorded by the source corpus.
Background Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. Methods and Findings A total of 3,274 uncircumcised men, aged 18–24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the intervention group immediately after randomization and to the control group at the end of the follow-up. The grouped censored data were analyzed in intention-to-treat, univariate and multivariate, analyses, using piecewise exponential, proportional hazards models. Rate ratios (RR) of HIV incidence were determined with 95% CI. Protection against HIV infection was calculated as 1 − RR. The trial was stopped at the interim analysis, and the mean (interquartile range) follow-up was 18.1 mo (13.0–21.0) when the data were analyzed. There were 20 HIV infections (incidence rate = 0.85 per 100 person-years) in the intervention group and 49 (2.1 per 100 person-years) in the control group, corresponding to an RR of 0.40 (95% CI: 0.24%–0.68%; p < 0.001). This RR corresponds to a protection of 60% (95% CI: 32%–76%). When controlling for behavioural factors, including sexual behaviour that increased slightly in the intervention group, condom use, and health-seeking behaviour, the protection was of 61% (95% CI: 34%–77%). Conclusion Male circumcision provides a degree of protection against acquiring HIV infection, equivalent to what a vaccine of high efficacy would have achieved. Male circumcision may provide an important way of reducing the spread of HIV infection in sub-Saharan Africa. (Preliminary and partial results were presented at the International AIDS Society 2005 Conference, on 26 July 2005, in Rio de Janeiro, Brazil.)
Subfields: Public Health, Environmental and Occupational Health, Surgery
View Paper: https://www.semanticscholar.org/paper/a928e37940a2c368d6e4eaa675e5d098b4cb7e68
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In Public Health, Environmental and Occupational Health
In Surgery
Citations in the corpus
- A framework for public health action: the health impact pyramid. (2010, background): “Male circumcision, a minor outpatient surgical procedure, can decrease female-to-male HIV transmission by as much as 60%.(34) Scale-up could potentially prevent millions of HIV infections in sub-Saharan Africa.”
- Glaser or Strauss? Considerations for selecting a grounded theory study (2016, neutral): “While a number of feasibility and acceptability studies (Auvert et al., 2005; Auvert et al., 2008; Kahn, Marseille, & Auvert, 2006; Siegfried et al., 2003; Siegfried et al., 2005) have been conducted, there are no empirical studies on the meanings that key individuals attach to VMAMC.”