Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.

By P. Sargent, K. H. Kjaer, C. Bench, Eugenii A. Rabiner, C. Messa, J. Meyer, Roger N. Gunn, P. Grasby, P. Cowen. Archives of General Psychiatry, 2000

678 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/a8c6b089a8248d9b26eff2844c40126b54dbb7f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Wayne C. Drevets
2. Joseph L. Price
3. Jaak Panksepp
4. D. Watt
5. Bradford C. Dickerson
6. Howard Eichenbaum
7. Wolfram Schultz

In Pharmacology

1. Joseph L. Price
2. Maura L. Furey
3. Wayne C. Drevets
4. David J. Kupfer
5. R. Duman
6. G. Agam
7. R. Belmaker

In Radiology, Nuclear Medicine and Imaging

1. Joseph L. Price
2. Wayne C. Drevets

Citations in the corpus

• Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “…insula, cingulate, parieto-occipital and orbital/ventrolateral prefrontal cortices in most studies of MDD and BD (e.g., Drevets et al. 1999, 2007; Sargent et al. 2000; Lopez et al. 1998), and the thermic and adrenocorticotropin/cortisol responses to 5-HT1A receptor agonist challenge are blunted…”
• Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “Additionally, brain imaging studies (Drevets et al., 1999; Sargent et al., 2000) have reported a reduction in 5-HT1a receptor binding—both pre- and postsynaptically, in the raphe as well as in medial temporal areas—that may be a marker of vulnerability to depression, as this apparently does not…”
• Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. (2000, background): “Serotonin 1A receptor decreases have also been reported, with described selective changes in the hippocampus (Drevets et al 1999; Sargent et al 2000), perhaps related to reported volume loss in this region with chronic depression (Sheline et al 1996).”
• Neuroimaging studies of mood disorders. (2000, methodology): “Finally, the 5-HT 1A receptor imaging studies using PET and [carbonyl- 11 C]WAY-100635 (Drevets et al 1999a; Sargent et al 2000) converge with in vitro studies acquired postmortem (Bowen et al 1989; López et al 1998) or antemortem (Francis et al 1989) to indicate that 5-HT 1A receptor binding is…”
• A Research Agenda For DSM-V (2002, result): “The decreases in 5-HT1A receptor found in these studies are consistent with findings from PET studies using 5-HT1A ligands (Drevets et al. 1999; Sargent et al. 2000).”