Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.

By K. Sokolov, M. Follen, J. Aaron, Ina Pavlova, A. Malpica, R. Lotan, R. Richards-Kortum. Cancer Research, 2003

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Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. (2005, background): “[193] Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R.”
Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. (2007, background): “showed that gold nanoparticles can be targeted molecularly to cancer cells and tissue by conjugation with anti-epidermal growth factor receptor (anti-EGFR) antibodies [98].”
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. (2008, background): “[14], and catalytic [15] properties have been exploited in the areas of cancer imaging [2,16–19], diagnostics [6,20,21], and treatment [22–30].”
Molecular imaging and darkfield microspectroscopy of live cells using gold plasmonic nanoparticles (2009, methodology): “The work reviewed here has focused on darkfield imaging [16,18,64,65] but other imaging modalities can be used to detect nanoparticle imaging agents as well.”
Plasmonic photothermal therapy (PPTT) using gold nanoparticles (2008, background): “For instance, anti-epidermal growth factor receptor (EGFR) antibodies can be employed to target overexpressed EGFR on oral cancer cells [89, 90, 92] and cervical cancer cells [136, 137], anti-Her2 for overexpressed Her2 on breast cancer cells [99] and seprase on breast cancer cells [88].”