Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

By J. Lan, J. Ge, Jinfang Yu, S. Shan, Huan Zhou, S. Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang and 1 more. 2020

5,505 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Infectious Diseases

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In Computational Theory and Mathematics

In Infectious Diseases

Citations in the corpus

Learning inverse folding from millions of predicted structures (2022, background): “Given potential applications to interface optimization or design, we focus on mutations within the receptor binding motif (RBM), the portion of the RBD in direct contact with ACE2 (Lan et al., 2020).”
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 (2020, positive): “…domain (RBD) in complex with ACE2 defined key residues involved in recognition and guide surveillance studies aiming to detect the emergence of mutants with altered binding affinity for ACE2 or distinct antigenicity (Lan et al., 2020; Shang et al., 2020; Wang et al., 2020b; Yan et al., 2020).”
The Global Phosphorylation Landscape of SARS-CoV-2 Infection (2020, neutral): “However, inspection of S in complex with the ACE2 receptor (Shang et al., 2020; Lan et al., 2020) reveals some of these phosphorylation sites to be near but not at the interface region.”
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology (2020, positive): “Superimposition of the SARS-CoV-2 RBD/ACE2 structures (Lan et al., 2020; Shang et al., 2020; Wang et al., 2020b; Yan et al., 2020) onto the SARS-CoV-2 S/S2H13 complex reveals that S2H13 and ACE2 would clash upon binding to S and that they share partially overlapping binding sites although they have…”
A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures (2020, background): “Contact residues previously identified by crystal structures 19,20,33 .”
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization (2021, background): “The impact of SARS-CoV-2 adaptation for infection of other hosts including mice (Dinnon et al., 2020; Gu et al., 2020), mink (Oude Munnink et al., 2021), and domesticated animals (Halfmann et al., 2020; Shi et al., 2020) could also contribute to selection of new variants.”
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals (2020, neutral): “The receptor-binding domain (RBD) of S protein (S-RBD) and main protease (Lan et al., 2020) were produced by a Baculovirus insect expression system and purified to a purity of 90% (Figure S1A).”