Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition.

By R. Kootte, Evgeni Levin, J. Salojärvi, L. Smits, Annick V. Hartstra, S. D. Udayappan, Gerben D. A. Hermes, K. Bouter, Annefleur M. Koopen, Jens J. Holst and 18 more. Cell Metabolism, 2017

907 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0940afc25fd86641e94b59c3d23a03aecfbcad15

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In Molecular Biology

1. Eran Elinav
2. Eran Segal
3. Shalev Itzkovitz
4. J. Durack
5. S. Lynch
6. Jotham Suez
7. N. Zmora

In Physiology

1. Eran Segal
2. Eran Elinav

Citations in the corpus

• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Gut microbiome and chronic inflammatory disease 32 successful (albeit short-lived) engraftment of lean-donor FMT and improved health in men with metabolic syndrome (Kootte et al., 2017), suggesting a role for GABA in glucose metabolism in humans.”
• Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT. (2018, background): “Of note, while aFMT is increasingly studied in various clinical contexts (Kootte et al., 2017) and promoted through non-medical channels and bio-banking entities (Smith et al.”
• Short chain fatty acids in human gut and metabolic health. (2020, neutral): “Compared to colonic levels, the plasma concentrations of the three main SCFA are very low: 5-220; <8; <10 µM for acetate, propionate and butyrate, respectively (Bouter et al. , 2018; Kootte et al. , 2017; Neis et al. , 2018; Van der Beek et al. , 2015).”
• The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “In contrast, post-FMT community composition was only mildly associated with recipient pre-FMT composition in trials on metabolic syndrome (Kootte et al., 2017) and ulcerative colitis (Fuentes et al.”
• Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “In patients with metabolic syndrome, FMT was shown to improve insulin sensitivity for those with decreased baseline microbial diversity, but the effects did not persist in the long-term [77].”