Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction

By W. Lau, L. Waskell, P. Watkins, Charlene J. Neer, Kevin Horowitz, Amy S Hopp, A. Tait, D. Carville, K. Guyer, E. Bates. Circulation, 2003

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Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine (2016, background): “In another case, the antiplatelet activity of clopidogrel was reduced when it was administered with proton pump inhibitors such as esomeprazole and omeprazole owing to the inhibition of CYP2C19 [169], whereas an increased activity of clopidogrel was anticipated in the presence of rifampicin and aspi”
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. (2008, background): “Dysfunctional cytochrome P450 metabolism has also been shown when clopidogrel was associated with various drugs such as atorvastatin ( 4 ,12).”
Drug interactions with lipid‐lowering drugs: Mechanisms and clinical relevance (2006, background): “In experimental studies in humans, atorvastatin but not pravastatin has decreased the inhibitory effect of clopidogrel on platelet aggregation”