Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
By M. Gilard, B. Arnaud, J. Cornily, G. Le Gal, K. Lacut, G. Le Calvez, J. Mansourati, D. Mottier, J. Abgrall, J. Boschat. Journal of the American College of Cardiology, 2008
1,084 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Hematology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/92be96bc6d1d19897a6122e22163ac24efc285d3
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- A population-based study of the drug interaction between proton pump inhibitors and clopidogrel (2009, background): “Among high-risk angioplasty patients treated with ASA and clopidogrel, use of omeprazole significantly reduced the antiplatelet activity of clopidogrel.(14) In a series of patients taking clopidogrel, the risk of acute myocardial infarction was more than 300% higher among those who were highly adher”
- Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. (2009, methodology): “Recent mechanistic studies, however, suggest that PPIs may reduce the inhibitory effect of clopidogrel on platelet aggregation.(4,5) In addition, variations in platelet reactivity have been associated with adverse outcomes following stent implantation.”
- 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST‐Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) (2009, background): “The PPI omeprazole notably has been reported to significantly decrease the inhibitory effect of clopidogrel on platelet aggregation.(63,64) One study reported that the PPI pantoprazole was not associated with recurrent MI among patients receiving clopidogrel, possibly because of its lack of inhibiti”