Association of electronic cigarette use with initiation of combustible tobacco product smoking in early adolescence
By A. Leventhal, D. Strong, M. Kirkpatrick, Jennifer B. Unger, Steve Sussman, N. Riggs, Matthew D Stone, Rubin Khoddam, J. Samet, J. Audrain-McGovern. Journal of the American Medical Association (JAMA), 2015
889 citations recorded by the source corpus.
Importance Exposure to nicotine in electronic (e-) cigarettes is common among adolescents who report never having smoked combustible tobacco. Objectives To evaluate whether e-cigarette ever-use among 14-year-olds who have never tried combustible tobacco is associated with risk of initiating use of three combustible tobacco products (i.e., cigarettes, cigars, and hookah). Design Longitudinal repeated assessment of a school-based cohort at baseline (fall 2013, 9th grade, Mean age=14.1) and 6-month (spring 2014, 9th grade) and 12-month (fall 2014, 10th grade) follow-ups. Setting and Participants Ten public high schools in Los Angeles, CA were recruited through convenience sampling. Participants were students who reported never using combustible tobacco at baseline and underwent follow-up assessment (N=2,530). At each time point, students completed self-report surveys during in-classroom data collections. Exposure Self-report of e-cigarette ever-use (yes/no) at baseline. Main Outcome Measures Six- and 12-month follow-up reports of use of each of the following tobacco products within the prior 6 months: (1) any combustible tobacco product (yes/no); (2) combustible cigarettes (yes/no), (3) cigars (yes/no); (4) hookah (yes/no); and (5) number of combustible tobacco products (range: 0–3). Results Past 6-month use of any combustible tobacco product was more frequent in baseline e-cigarette ever-users (N=222) than never-users (N=2,308) at the 6-month (30.7% vs. 8.1%, % difference [95% CI]=22.7[16.4, 28.9]) and 12-month (25.2% vs. 9.3%, % difference [95% CI]= 15.9[10.0, 21.8]) follow-ups. Baseline ever e-cigarette use was associated with greater likelihood of combustible tobacco use averaged across the two follow-ups in unadjusted analyses (OR[95% CI]=4.27[3.19, 5.71]) and in analyses adjusted for sociodemographic, environmental, and intrapersonal risk factors for smoking (OR[95% CI]=2.73[2.00, 3.73]). Product-specific analyses showed that baseline e-cigarette ever-use was positively associated with combustible cigarette (OR[95% CI]=2.65[1.73, 4.05]), cigar (OR[95% CI]=4.85[3.38, 6.96]), and hookah (OR[95% CI]=3.25[2.29, 4.62]) use and number of different combustible products used (OR[95% CI]=4.26[3.16, 5.74]) averaged across the two follow-ups. Conclusion and Relevance Among high school students in Los Angeles, those who used electronic cigarettes at baseline compared with nonusers were more likely to report initiation of combustible tobacco smoking over the next year. Further research is needed to understand whether this association may be causal.
Subfields: Epidemiology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/a7deba5e1801b78652c5a1f8f9e7ed8a9808498c
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Citations in the corpus
- Cancer Progress and Priorities: Lung Cancer (2019, background): “youths is associatedwith increased risk of initiation of traditional cigarette use (63, 64).”
- Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults (2017, background): “tially occurs among youth who are not at high risk for cigarette smoking based on established risk factors.(4,5,33) For example,Wills et al(34) found that the effect of e-cigarette use on cigarette smoking initiation was stronger among study par-”
- 5. Lifestyle Management: Standards of Medical Care in Diabetes—2019 (2018, background): “Nonsmokers should be advised not to use e-cigarettes (180,181).”