Origin, evolution and genome distribution of microsatellites

By E. J. Oliveira, J. G. Pádua, Maria Imaculada Zucchi, R. Vencovsky, M. L. C. Vieira. 2006

406 citations recorded by the source corpus.

Microsatellites, or simple sequence repeats (SSRs), have been the most widely applied class of molecular markers used in genetic studies, with applications in many fields of genetics including genetic conservation, population genetics, molecular breeding, and paternity testing. This range of applications is due to the fact that microsatellite markers are co-dominant and multi-allelic, are highly reproducible, have high-resolution and are based on the polymerase chain reaction (PCR). When first introduced, the development of microsatellite markers was expensive but now new and efficient methods of repetitive sequence isolation have been reported, which have led to reduced costs and microsatellite-technology has been increasingly applied to several species, including non-model organisms. The advent of microsatellite markers revolutionized the use of molecular markers but the development of biometric methods for analyzing microsatellite data has not accompanied the progress in the application of these markers, with more effort being need to obtain information on the evolution of the repetitive sequences, which constitute microsatellites in order to formulate models that fit the characteristics of such markers. Our review describes the genetic nature of microsatellites, the mechanisms and models of mutation that control their evolution and aspects related to their genesis, distribution and transferability between taxa. The implications of the use of microsatellites as a tool for estimating genetic parameters are also discussed.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7b31ad076696619b635731de73061820f9cd520

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Citations in the corpus

Microsatellite markers: what they mean and why they are so useful (2016, background): “…of articles over the past two decades, some of which are highlighted here: Jarne and Lagoda (1996); Schlötterer (1998); Li et al. (2002); Buschiazzo and Gemmell (2006); Oliveira et al. (2006); Sun et al. (2009); Guichoux et al. (2011); Gemayel et al. (2012); Senan et al. (2014); Mason (2015).”
Current trends in microsatellite genotyping (2011, background): “…(Tautz & Schlötterer 1994; Jarne & Lagoda 1996; Schlötterer 1998; Chambers & MacAvoy 2000; Li et al. 2002; Dieringer & Schlötterer 2003; Ellegren 2004; Buschiazzo & Gemmell 2006; Chistiakov et al. 2006; Oliveira et al. 2006; Selkoe & Toonen 2006; Subirana & Messeguer 2008; Sun et al. 2009).”
Methods for Development of Microsatellite Markers: An Overview (2014, neutral): “Based on the type of repeat sequence Four types of SSRs (Oliveira et al., 2006): a. Perfect microsatellite- the repeat sequence is continuous and is not interrupted by any base not belonging to the motif [e.g. AGAGAGAGAGAG or (AG)6] b. Imperfect microsatellite- a pair of bases is present between…”