CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
By M. Tiemessen, A. Jagger, H. Evans, M. V. van Herwijnen, S. John, L. Taams. Proceedings of the National Academy of Sciences of the United States of America, 2007
864 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/a79f9cc9241b92d7c4fa19a81ef92dda9065b319
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- D. Gabrilovich
- S. Ostrand-Rosenberg
- V. Bronte
- TA Wynn
- Lisa M. Coussens
- S. Galli
- D. DeNardo
- J. Barreto
Citations in the corpus
- Normalization of Obesity-Associated Insulin Resistance through Immunotherapy: CD4+ T Cells Control Glucose Homeostasis (2009, background): “In contrast, anti-inflammatory IL-4 and IL-13–secreting T cells (T H 2), as well as CD4 + Foxp3 + regulatory T cells, modify macrophage function by inducing their differentiation into anti-inflammatory, IL-10–secreting M2, or 'alternatively activated', macrophages (AAMs”
- Efficient clearance of early apoptotic cells by human macrophages requires “M2c” polarization and MerTK induction (2012, background): “(50) reported that Tregs promote anti-inflammatory monocytesmacrophages expressing CD163 and CD206; however, although”
- Coordinated regulation of myeloid cells by tumours (2012, background): “T Reg cell production of IL-10, IL-4 and IL-13 promotes the non-responsiveness of macrophages to LP”
- CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “…and found significantly elevated expression of factors indicative of an M1 activation state (e.g., TNF-a and Nos2) with parallel reduction in M2-type factors (e.g., In vitro, both CD4 + T effector and T reg cells have the capacity to modulate macrophage cytokine expression (Tiemessen et al., 2007).”
- Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011, background): “A role for CD4 + CD25 + Foxp3 + regulatory T cells in the polarization of human M2-like macrophages has also been describe”