Determination of elastic moduli of thin layers of soft material using the atomic force microscope.

By E. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, R. Chadwick. Biophysical Journal, 2002

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Tensile forces govern germ-layer organization in zebrafish (2008, methodology): “Such beads were used as an indenter to create a large and smooth contact geometry with the cell, hence reducing the strain induced by the pressure during contac”
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, methodology): “indentation data using a thin-layer Hertz model that accounts for cell thickness [24].”
Myotubes differentiate optimally on substrates with tissue-like stiffness (2004, methodology): “Mechanics of gels The elastic modulus of various gels was determined by AFM as well as macroscopic methods (Dimitriadis et al., 2002; Engler et al., 2004a).”
Microrheology of human lung epithelial cells measured by atomic force microscopy. (2003, background): “For a spherical indenter, this overestimation can be approximated as ;(Rd)/t, where t is the thickness of the sample (Dimitriadis et al., 2002).”
An analysis of nanoindentation in linearly elastic solids (2008, methodology): “These authors generally perceived the finite tip radius effect as a deviation from the estimated projected tip area, A. Doerner and Nix (1986) calibrated the tip area function, A(hc) of the indenter using careful measurements from transmission electron microscopy (TEM) images (proposed by Pethica…”