Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.
By C. S. Raymond, Mark W Murphy, M. G. O’Sullivan, V. Bardwell, D. Zarkower. Genes & Development, 2000
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The only molecular similarity in sex determination found so far among phyla is between the Drosophila doublesex (dsx) and Caenorhabditis elegans mab-3 genes. dsx and mab-3 contain a zinc finger-like DNA-binding motif called the DM domain, perform several related regulatory functions, and are at least partially interchangeable in vivo. A DM domain gene called Dmrt1 has been implicated in male gonad development in a variety of vertebrates, on the basis of embryonic expression and chromosomal location. Such evidence is highly suggestive of a conserved role(s) for Dmrt1 in vertebrate sexual development, but there has been no functional analysis of this gene in any species. Here we show that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene. As in the case of 9p deletions, Dmrt1 is dispensable for ovary development in the mouse. Thus, as in invertebrates, a DM domain gene regulates vertebrate male development.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a6fda55d131921de9577be2be169d310bd16541b
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Citations in the corpus
- Weird Animal Genomes and the Evolution of Vertebrate Sex and Sex Chromosomes (2008, background): “The most promising candidate remains a sex-reversal gene on human chromosome 9 (19, 66), whose orthologue lies on the chicken Z, but not the W even in ratites with homomorphic sex chromosomes (72).”
- Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. (2009, neutral): “DMRT1 is required for postnatal testis differentiation in mice and its homologs have been shown or suggested to be master sex-determining genes in the chicken and in some medaka species (Guiguen et al., 2009; Raymond et al., 2000; Smith et al., 2009).”
- Sex determination and gonadal development in mammals. (2007, background): “Moreover, in humans, mice, chickens, alligators, and turtles, Dmrt1 expression was detected in the developing gonads, and only the gonads (59, 124, 160, 194, 216), at higher levels in testes compared with ovaries, usually in the late sex-determining or early testis-differentiation period.”
- Evolution of alternative sex-determining mechanisms in teleost fishes (2006, background): “Locus DMRT1 is typically a downstream component in sexdetermination cascades, and has homologies throughout the animal kingdom, from invertebrates (Baker & Ridge, 1980; Shen & Hodgkin, 1988) to mammals (Raymond et al., 2000).”