Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity

By P. Lipsky. Nature Immunology, 2001

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Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “B cells not only secret antibodies, but also impact immune response by production of various cytokines and growth factors, antigen presentation, regulation of T cell activation and differentiation, and regulation of lymphoid organization [17].”
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood (2003, background): “SLE patients paradoxically display polyclonal hypergammaglobulinemia concomitantly with B and T lymphopenia (8, 9).”
Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis (2007, background): “Of note, IL-10 is also an established growth factor for B cells (33), and B cells isolated from patients with systemic lupus erythematosus and possibly rheumatoid arthritis and Sjogren’s syndrome were found to produce more IL-10 than normal B cells (34, 35).”