Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia.
By D. Umbricht, L. Schmid, R. Koller, Franz X. Vollenweider, D. Hell, Daniel C. Javitt. Archives of General Psychiatry, 2000
600 citations recorded by the source corpus.
Subfields: Cognitive Neuroscience, Pharmacology
View Paper: https://www.semanticscholar.org/paper/a6b365f76052d1b4699844ea53c2d9e02729e066
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In Cognitive Neuroscience
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In Pharmacology
Citations in the corpus
- Synaptic plasticity and dysconnection in schizophrenia. (2006, background): “…ERPs of Sensory Learning in Patients can be Mimicked by Pharmacological NMDA Blockage in Healthy Controls Subjects Kreitschmann-Andermahr et al 2001 Umbricht et al 2000 Replicated finding Candidate Genes Identified in Genetic Studies Harrison and Weinberger 2005 (review) Almost all genes are…”
- Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring (2009, result): “For example, the NMDA antagonist ketamine reduces the MMN in healthy volunteers, rendering it very similar to that of patients.(54,55) Furthermore, invasive recording studies in monkeys with local infusion of ketamine have demonstrated the dependence of the MMN on NMDARmediated synaptic plasticity;(”
- The mismatch negativity: A review of underlying mechanisms (2009, background): “…reductions of MMN amplitude under the NMDA antagonist ketamine (Ehrlichman et al., 2008; Heekeren et al., 2008; Javitt et al., 1996; Kreitschmann-Andermahr et al., 2001; Umbricht et al., 2000, 2002), with only a single study failing to find a significant effect of ketamine (Oranje et al., 2002).”
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. (2008, background): “In laboratory experiments, a subanesthetic dose of ketamine given to normal volunteers induces the symptoms of schizophrenia more effectively than any other known drug [29–32].”
- ERP Repetition Effects and Mismatch Negativity Generation A Predictive Coding Perspective (2007, background): “…evidence for a NMDA receptor role in MMN generation comes from studies in monkeys (Javitt, Steinschneider, Schroeder, & Arezzo, 1996) and humans (Umbricht et al., 2000), however, no specific test of RP effects was possible in those studies (see also reviews by Kahkonen, 2006; Umbricht & Krljes,…”
- The Computational Anatomy of Psychosis (2013, methodology): “• Abnormal event-related potentials: such as a larger P50 response to a repeated stimulus, and reduced P300 and mismatch negativity (MMN) responses to violations or oddball stimuli.”
- A theory of cortical responses (2005, background): “Umbricht et al. (2000) show that ketamine significantly decreases the MMN amplitude, to both pitch and duration, by about 20%.”