Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment…

By Avshalom Caspi, Terrie E. Moffitt, M. Cannon, J. McClay, R. Murray, H. Harrington, Alan H. Taylor, Louise Arseneault, B. Williams, Antony W. Braithwaite and 2 more. Biological Psychiatry, 2005

1,312 citations recorded by the source corpus.

Subfields: Epidemiology, Pharmacology, Toxicology

View Paper: https://www.semanticscholar.org/paper/a690098bc009320e2d1f317ed68e242769c8c92e

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In Epidemiology

1. Julia Kim-Cohen
2. J. van Os
3. Terrie E. Moffitt
4. M. Ungar

Citations in the corpus

• Continuities and discontinuities in psychopathology between childhood and adult life. (2006, background): “Caspi et al. (2005) have now shown, using the Dunedin longitudinal study data, that the effect of early heavy cannabis use leading to a schizophrenia spectrum disorder is a function of the valine allelic variation in the catechol-O-methyltransferase (COMT) gene.”
• Gene-environment interplay and psychopathology: multiple varieties but real effects. (2006, methodology): “Schizophrenia spectrum disorders: molecular genetic and measured environment findings Caspi et al. (2005) used the Dunedin Longitudinal study to investigate the possibility of G · E with respect to the COMT valine allele and heavy early use of cannabis.”
• Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression (2009, background): “Surtees et al,25 2006 4175 (1950) 60 (41-80) 33 49 18 Crosssectional No List of Threatening Eventsb Major depression (DSM-IV) Failed to replicate”
• A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry (2011, positive): “Similarly, G×Es could provide compelling explanations for why one person becomes depressed in response to severe life stressors while another does not (1), or why cannabis use increases risk for psychosis in one person but not in another (2).”
• Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. (2008, background): “Several studies suggest that valine-allele carriers may indeed be more sensitive to the psychotogenic effects of drugs of abuse or stress.(51,85,86)”