The influence of surface modification on the cytotoxicity of PAMAM dendrimers.

By Rachaneekorn Jevprasesphant, Jeffrey Penny, R. Jalal, David Attwood, Neil B. McKeown, A. D'emanuele. International journal of pharmaceutics, 2003

664 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, background): “Dendrimer modification with chemically inert polyethylene glycol (PEG) or fatty acids is one of the most attractive ways to reduce dendrimer toxicities in vitro [35,42-44].”
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “PEI, dendrimers [80], PLL [81], liposomes [82], and even viral vectors, such as adenoviruses [83].”
Role of nanotechnology in targeted drug delivery and imaging: a concise review. (2005, background): “Partial derivatization of the dendrimer surface, such as PAMAM dendrimer with PEG or fatty acids, helps to reduce toxicity and immunogenicity significantly due to a reduction/shielding of the positive charge on the dendrimer surface by the attached chains [190,191].”
Designing dendrimers for biological applications (2005, background): “3 ), generally display concentration-dependent toxicity and hemolysi”
Delivery of siRNA Therapeutics: Barriers and Carriers (2010, background): “Cationic polyamidoamine (PAMAM, amino-terminated surface) is more cytotoxic than anionic PAMAM (carboxylateterminated surface) in Caco-2 cells ( 69 ).”