The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes

By G. Chrousos. International Journal of Obesity, 2000

667 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/a67c0c78c473af377a556095216d66c2397b8f5b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. T. Glass
2. George P. Chrousos
3. Bruce S. McEwen
4. M. Mcatee

In Endocrinology, Diabetes and Metabolism

1. R. Juster
2. T. Glass
3. George P. Chrousos
4. G. Kaltsas
5. Sonia J. Lupien
6. Bruce S. McEwen
7. M. Mcatee
8. E. Kassi

In Physiology

1. Sonia J. Lupien
2. R. Juster
3. T. Glass
4. George P. Chrousos
5. Bruce S. McEwen
6. M. Mcatee
7. J. Wingfield
8. Carol Worthman

Citations in the corpus

• Behavioral science at the crossroads in public health: extending horizons, envisioning the future. (2006, background): “Human and animal studies showing that environmental stress alters core features of the appetite regulation system, and the metabolic parameters underlying it, offer convincing evidence of this view (Bjorntorp & Rosmond, 2000; Chrousos, 2000; Epel et al., 2004; Spiegel et al., 2004; Tataranni et al.,”
• Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “…Bogardus, 2009; Stumvoll et al., 2003, 2004), and incorporation of biomarkers not currently included in metabolic syndrome nomenclature (i.e., leptin, cortisol; (Chrousos, 2000; Kahn et al., 2005; Maggio et al., 2006, 2007; Rosmond, 2005)) will be essential for research and clinical practice alike.”
• Metabolic syndrome: definitions and controversies (2011, background): “Stress-related IL-6 hypersecretion plus adipose-tissue-generated inflammatory hypercytokinemia, as well as hypercortisolism, contribute to increased production of acute phase reactants and blood hypercoagulation, which have been recently recognized as components of MetS [84,85].”
• Insulin resistance: Genetic associations with depression and cognition in population based cohorts (2019, neutral): “For example, previous literature implicates low grade inflammation (Liu et al., 2012) as well as activation of the hypothalamic–pituitary–adrenocortical (HPA) axis and of the sympathetic nervous system (Chrousos, 2000; Weber-Hamann et al., 2002).”