Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
By Yi-hu Dong, Lian‐Hui Wang, Jin‐Ling Xu, Hai-Bao Zhang, Xi-Fen Zhang, Lian-Hui Zhang. Nature, 2001
1,022 citations recorded by the source corpus.
Subfields: Genetics, Microbiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a6323818d0e30bb38c028fc1ab2ac08d9632fadc
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In Genetics
- B. Bassler
- Christopher M. Waters
- Yung-Hua Li
- Xiaolin Tian
- T. Defoirdt
- N. Boon
- W. Verstraete
- Peter Bossier
In Molecular Biology
- M. Givskov
- B. Bassler
- T. Bjarnsholt
- T. Defoirdt
- Christopher M. Waters
- Peter Bossier
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- Xiaolin Tian
Citations in the corpus
- Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “AiiA is extremely nonspecific with regard to the AHL acyl side chain, which suggests that this strategy interferes generically with AHL-mediated communication between gram-negative bacteria (Dong et al. 2001).”
- Targeting virulence: a new paradigm for antimicrobial therapy (2007, background): “For example, Gram-positive Bacillus species produce acylhomoserine lactonase, an enzyme that hydrolyzes the lactone ring of AHLs, thereby rendering them unable to mediate signalin”
- Control of blackleg and tuber soft rot of potato caused by Pectobacterium and Dickeya species: a review. (2011, background): “Either symptom expression was entirely blocked or symptoms development was significantly reduced (Dong et al., 2001).”
- Top 10 plant pathogenic bacteria in molecular plant pathology. (2012, background): “The crucial importance of quorum sensing pectobacterial pathogenesis was confirmed by studies on genetically engineered plants (Dong et al., 2001; Toth et al., 2004).”
- Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture (2004, background): “Electrospray ionisation-mass spectrometry of the hydrolysis product revealed that the AiiA enzyme opens the lactone ring to produce N-(3-oxohexanoyl)-l-homoserine (Dong et al., 2001).”
- The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, background): “Lactonolysis of the AHL ring leads to an inactive product that no longer activates the AHL QS system, with consequent attenuation of virulence, as observed in various infection models (31, 55, 149, 188).”