Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis

By D. Franchimont, Severine Vermeire, H. Housni, M. Pierik, K. Steen, T. Gustot, E. Quertinmont, M. Abramowicz, A. V. Gossum, J. Devière and 1 more. Gut, 2004

657 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/a5d7a85aff08f8a5d1bf2d43eaaa2ff7989134c1

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In Genetics

1. R. Sartor
2. P. Rutgeerts
3. J. Turner

In Immunology

1. R. Sartor

Citations in the corpus

• Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives (2011, background): “and inflammatory bowel disease (IBD) has been demonstrated.”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Caucasian CD and UC populations shared the mutation D299G in Toll-like receptors 4 (TLR4) [95], while variants of IL-23R and IL-17A have been found in subsets of Korean UC and CD populations [96, 97].”
• VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis (2005, background): “of patients) (%) Rectum, sigmoid 4 (12) Distal to the mid transverse colon 23 (67) Pancolitis 7 (21) Concomitant medications (%) Corticosteroids oral∗ 5 (15) Corticosteroid enema∗ 4 (12) Azathioprine or 6-mercaptopurine∗ 6 (18) Antibiotics None Mesalamine oral∗ 25 (74) Mesalamine enema∗ 4 (12) None ”