Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila

By Jeffrey M. Donlea, M. Thimgan, Yasuko Suzuki, L. Gottschalk, P. Shaw. 2011

352 citations recorded by the source corpus.

Inducing sleep in flies reverses deficits in long-term memory caused by social enrichment. Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Endocrine and Autonomic Systems

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, neutral): “DOI: 10.7554/eLife.04580 17 of 42 Research article Donlea et al., 2011).”
About sleep's role in memory. (2013, methodology): “These studies exemplify the rapid development of new genetic tools that can be used as the “remote control” of sleep (316) and, in this way, to study the function of sleep for memory consolidation.”
The Biology of Forgetting – A Perspective (2017, background): “a sleep or rest episode after learning in humans and in a wide range of other organisms (Diekelmann andBorn, 2010), including in fruit flies (Donlea et al., 2011).”
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster (2015, background): “Sleep deprivation following an associative learning task impairs consolidated memory in Drosophila, rodents, and humans whereas sleep immediately after a learning task actually improves consolidated memory across the same broad range of organisms (Ganguly-Fitzgerald et al., 2006; Donlea et al., 2011”
Sleep prevents catastrophic forgetting in spiking neural networks by forming a joint synaptic weight representation (2022, background): “From a functional perspective, this includes local synaptic plasticity, combination of different plasticity rules and sleep-wake cycle that was shown to be critical for memory and learning in variety of species from insects [24–26] to vertebrates [16].”
Drosophila strategies to study psychiatric disorders. (2013, background): “A recent study showing that it is now possible to induce sleep on demand in Drosophila [46] suggests that the fly model might shed some light on cause and effect between sleep disorders and cognitive disorders.”
Sleep facilitates memory by blocking dopamine neuron mediated forgetting (2015, neutral): “, 2001) and long-term courtship memory in Drosophila (Donlea et al., 2011).”
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection (2020, background): “, 2011), memory formation and consolidation (Berry et al., 2015; Dag et al., 2019; Donlea et al., 2011), changes in gene expression (Cirelli et al.”
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, background): “Moreover, the number or size of synapses in four different neural circuits increases after a few hours of wake and decreases only if flies are allowed to sleep (Bushey et al., 2011; Donlea et al., 2009, 2011).”
Propagation of homeostatic sleep signals by segregated synaptic microcircuits of the Drosophila mushroom body (2015, neutral): “, [42, 46]) and our recent discovery that sleep-regulating MBONg5b02a/b02mp/b02mp_bilateral and MBON-g2a01 are also important for some forms of associative learning [19], it will be of great interest to determine how activity of the sleep-controlling MB synaptic microcircuits influences memory forma”