p53 status determines the role of autophagy in pancreatic tumour development

By M. Rosenfeldt, J. O'prey, J. Morton, C. Nixon, G. Mackay, Agata Mrowinska, Amy Y. M. Au, T. S. Rai, Liang Zheng, Rachel A. Ridgway and 5 more. Nature, 2013

689 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/a57cf99cfa537b17acd00db3357ffddaaceb1f1c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Alec C. Kimmelman
2. Guido Kroemer
3. L. Galluzzi
4. E. White
5. R. Amaravadi
6. Beth Levine
7. Douglas R. Green
8. N. Mizushima

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Alec C. Kimmelman
4. R. Amaravadi
5. J. B. Pedro
6. P. Porporato
7. N. Filigheddu
8. E. White

In Surgery

1. Guido Kroemer
2. Alec C. Kimmelman

Citations in the corpus

• Autophagy, Metabolism, and Cancer (2015, neutral): “Despite increased PANIN, these lesions are impaired for progression to invasive cancer, which increases mouse survival (18, 19).”
• Autophagy and Tumor Metabolism (2017, background): “informative and helped define the critical role of autophagy in multiple cancers, including pancreatic cancer (Rosenfeldt et al., 2013; Yang and Kimmelman, 2014), lung cancer (Guo et al.”
• Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth (2015, neutral): “…+ 8 3+ 1+ + 9 2+ 2+ partial 10 2+/3+ 1+ + 11 3+ 1+/2+ + 12 3+ 1+ + M T C 02 /D A P I C (legend on next page) 546 Molecular Cell 57, 537–551, February 5, 2015 ª2015 Elsevier Inc. et al., 2011; Lock et al., 2011; Rao et al., 2014; Rosenfeldt et al., 2013; Son et al., 2013; Strohecker et al., 2013).”
• Mitochondrial metabolism and cancer (2017, background): “Along similar lines, severe defects in autophagy or mitophagy – resulting in fully compromised mitochondrial functions – have been associated with decreased tumor progression in multiple models of oncogenesis [39, 64-66].”
• Autophagy in malignant transformation and cancer progression (2015, neutral): “Autophagic responses are indeed recovered along with tumor progression in various models of KRAS-driven oncogenesis (see below) (Guo et al , 2013a; Rosenfeldt et al , 2013; Rao et al , 2014).”
• Recent insights into the function of autophagy in cancer (2016, background): “The most characterized of these started with a FAK inhibitor that potently inhibited ULK1 function (Russell et al. 2013; Egan et al. 2015).”