Mechanisms of p53-dependent apoptosis.
By Martin Schuler, Douglas R. Green. Biochemical Society Transactions, 2001
682 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/a51bfe64f7ef9c3399b6cb0062e14e55b7bd7caf
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Citations in the corpus
- Hypoxia-Inducible Factor-1 (HIF-1) (2006, unknown): “In addition, p53 has been implicated in regulating hypoxia-induced apoptosis through induction of apoptosis-related genes such as Bax, NOXA, PUMA, and PERP (Schuler and Green, 2001).”
- Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “However, p53 can trigger elimination of the damaged cells by promoting apoptosis through the upregulation of proapoptotic genes such as Bax, NOXA, TRAIL-R2 (DR5), and Fas (CD95/Apo-1) [12, 55, 126, 127].”
- Apoptosis: A Review of Programmed Cell Death (2007, background): “The tumor suppressor protein p53 has a critical role in regulation of the Bcl-2 family of proteins, however the exact mechanisms have not yet been completely elucidated (Schuler and Green, 2001).”
- p53 has a direct apoptogenic role at the mitochondria. (2003, background): “Here, cytosolic p53 can induce mitochondrial cytochrome c we provide evidence that p53 translocation to the mirelease (Schuler and Green, 2001).”
- Molecular mechanisms of drug resistance (2005, background): “However, depending on the cellular context, p53 can trigger elimination of the damaged cells by promoting apoptosis through the upregulation of pro-apoptotic genes such as Bax, NOXA, TRAIL-R2 (DR5 ), and Fas (CD95 /Apo-1 ) [113–116].”
- Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex (2004, background): “dtd" [ ]> The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresse”