Histone Modifications and Cancer.

By J. Audia, R. Campbell. Cold Spring Harbor Perspectives in Biology, 2016

859 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a50d9e2b465560fa8b3e355348389a2b709d7731

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In Molecular Biology

1. R. DePinho
2. Ping Gao
3. Sheng-yong Yang
4. Michael Olivier
5. Huafeng Zhang
6. L. Cox
7. Linchong Sun
8. D. Hanahan

Citations in the corpus

• Genetics and biology of prostate cancer (2018, background): “Histone modification (e.g., acetylation, methylation, and phosphorylation) also plays a prominent role in normal and neoplastic processes through the regulation of gene expression (Jenuwein and Allis 2001; Allis and Jenuwein 2016; Audia and Campbell 2016).”
• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “PADs contain five Ca2+-dependent enzymes (PAD 1-4 and PAD6) (Witalison et al., 2015; Audia and Campbell, 2016; Yuzhalin, 2019) (Fig.”
• The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “This includes alterations in DNA methylation [55], histone modifications [56], and expression of miRNAs [57] and lncRNAs [58,59].”
• Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. (2016, background): “Besides DNA modification, histone modifications are also known to play critical role in genome maintenance and carcinogenesis [47, 48].”
• Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “In addition to those mentioned and discussed above, histone modifications also include citrullination, ADP-ribosylation, deamination, formylation, O-GlcNAcylation, propionylation, butyrylation, crotonylation, and proline isomerization at over 60 amino acid residues.(157,158) In addition to conventio”
• Hallmarks of Cancer: New Dimensions. (2022, background): “Epigenomic heterogeneity is being revealed by increasingly powerful technologies for profiling genomewide DNA methylation (79, 80), histone modification (81), chromatin accessibility (82), and posttranscriptional modification and translation of RNA (83, 84).”