Colonic epithelial cell diversity in health and inflammatory bowel disease

By K. Parikh, A. Antanaviciute, D. Fawkner-Corbett, M. Jagielowicz, A. Aulicino, C. Lagerholm, S. Davis, J. Kinchen, Hannah H. Chen, N. K. Alham and 12 more. Nature, 2019

722 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/a4ef285d0a4ca9db6156eb370ef044422817807d

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Citations in the corpus

Cellular and inter-cellular rewiring of the human colon during ulcerative colitis (2019, background): “Our census revealed that enterocytes expressing BEST4 are distinct from other epithelial cells (Parikh et al., 2019), and are enriched in genes related to pH sensing and electrolyte balance (validated in situ, Figure 1G,H and S1D).”
Spatiotemporal analysis of human intestinal development at single-cell resolution (2021, positive): “, 2011), goblet cells (MUC2, SPDEF andWFDC2) (McCauley andGuasch, 2015; Parikh et al., 2019) and stem cells (LGR5, ASCL2 and SMOC2) (Barker, 2014).”
A single–cell type transcriptomics map of human tissues (2021, positive): “Here, we present a dataset containing 13 different human tissues covering most major organs in the human body including ileum (9), colon (10), rectum (9), kidney (11), liver (12), pancreas (13), heart (14), lung (15), prostate (16), testis (17), placenta 1Science for Life Laboratory, Department of P”
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses (2020, positive): “Totally, we curated single cell gene expression matrices of 13 human tissues, including lung[11], liver[12], ileum[13], rectum[13], blood[14], bone marrow[15], skin[16], spleen[17], esophagus[17], colon[18], eye[19], stomach[20] and”
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma (2020, background): “Upregulation of immunosuppressive components of the pulmonary epithelial barrier, including MUC5B and WFDC2 (HE4), was observed in the CTE cluster of lung tumors (Figure 5A, lower panel) (Parikh et al., 2019; Roy et al., 2014), and surfactants SFTPB, DMBT1, SFTPA1, and SFTPD were increased in tumors”
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “In IBD, intestinal epithelial goblet cells are positionally remodeled and coincided with the downregulation of WFDC2, which is an antiprotease molecule with the ability to preserve the integrity of tight junctions between epithelial cells and prevents invasion by bacteria and mucosal inflammation [5”