Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

By M. Leitges, L. Sanz, Pilar Martín, A. Duran, U. Braun, Juan F. García, F. Camacho, M. Diaz-Meco, P. Rennert, J. Moscat. 2001

372 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a4e5cf18903d9aa916e951e87d98208b98783e2f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Moscat
2. M. Diaz-Meco
3. A. Duran
4. Lin-Feng Chen
5. W. Greene
6. P. Rennert
7. S. Ghosh
8. N. Perkins

In Immunology

1. Lin-Feng Chen
2. W. Greene
3. M. Diaz-Meco
4. J. Moscat
5. A. Duran
6. S. Ghosh
7. N. Perkins
8. M. Hayden

In Oncology

1. J. Moscat
2. P. Rennert
3. Lin-Feng Chen
4. W. Greene

Citations in the corpus

• Role of ζPKC in B‐cell signaling and function (2002, methodology): “This defect is corrected in adult KO mice in which the content of the different major B-cell splenic subpopulations is normal (Leitges et al., 2001; this study).”
• NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, background): “members of the extended family of PKCs might be essential for B-cell function stems from the initial work of Leitges et al. (1996), who showed that PKC-β KO mice have impaired humoral immune responses and defective IgM-triggered B-cell proliferation, despite”
• Essential role of RelA Ser311 phosphorylation by ζPKC in NF‐κB transcriptional activation (2003, methodology): “What we show here is that zPKC, which we previously had described to phosphorylate the RHD of RelA directly in vitro (Leitges et al., 2001), targets Ser311.”
• Shaping the nuclear action of NF-κB (2004, background): “pl?Q05513">PKCζ , and this modification similarly enhances the overall transcriptional respons”