Regulatory T Cells

By Chris Corrigan, K. Ryanna. Methods in Molecular Biology, 2011

2,198 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a4b52bb454b01234829b3a46b39cd0338ff695d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer (2019, positive): “In tumor tissues, activated PD-1 Treg cells, which highly express CTLA-4, may result in more Treg: APC aggregates coupled with CTLA-4–dependent downregulation of the costimulatory molecules CD80 and CD86 on APCs, hence restricting APC access for Tconv cells and their activation (29, 30, 38).”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, neutral): “the activities of effector T cells (20).”
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma (2013, neutral): “Widespread depletion of T reg cells can induce multiple autoimmune pathologies (Fontenot et al., 2003; Kim et al., 2007).”
The PD-1 Pathway in Tolerance and Autoimmunity (2010, positive): “According to this model, effective activation of a naive T cell requires two signals delivered by antigen-presenting cells (APCs).”
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, neutral): “Although Treg cell-mediated suppression is not fully understood in mechanistic terms, various studies indicate that Treg cells utilizemultiplemeans to accomplish suppressionof different inflammatory responses (Shevach, 2009; Vignali et al., 2008).”
Plasticity of CD4+ T cell lineage differentiation. (2009, positive): “Treg cells have essential roles in maintenance of immune homeostasis, regulating these effector T cell responses and thus preventing their potentially pathogenic effects through a variety of mechanisms (Vignali et al., 2008; Shevach, 2009, this issue of Immunity).”
Regulatory T cells in tumor immunity (2010, positive): “suppression, it has been shown that Foxp3þTregs exert suppression, at least in vitro, by cell-to-cell contact with antigen presenting cells (APCs), such as DCs and effector T cells,(23,24) for example, via membrane TGF-b,(25,26) CTLA-4, perforin/granzyme,(30) extracellular adenosine,(31) gap junctio”